medication · 4 min read

How GLP-1 titration actually works

A no-jargon explanation of dose ramps and why they matter.

Why you start low

Your body needs to adapt. Starting at the maintenance dose causes severe side effects in most people.

The typical ramp

Semaglutide: 0.25 mg → 0.5 mg → 1.0 mg → 1.7 mg → 2.4 mg over 16+ weeks. Tirzepatide: 2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg over 20+ weeks.

Why some providers pause

If side effects exceed what you can handle at a given step, your prescriber holds you there until you can move up. There is no medal for finishing fast.

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