Laboratory microscope
Photo by Dan Cristian Pădureț on Unsplash
Research

The trials behind the headlines.

Plain-English summaries of the pivotal GLP-1 trials. Outcomes, populations, durations.

STEP 1 · 2021 · 68 wks

STEP 1 — Semaglutide for weight management

Pivotal trial of semaglutide 2.4 mg weekly for chronic weight management in adults without diabetes.

STEP 2 · 2021 · 68 wks

STEP 2 — Semaglutide in T2D

Semaglutide 2.4 mg in adults with overweight/obesity AND type 2 diabetes.

STEP 3 · 2021 · 68 wks

STEP 3 — Semaglutide plus intensive behavioral therapy

Semaglutide combined with intensive behavioral intervention.

STEP 4 · 2021 · 68 wks

STEP 4 — Effect of continued vs withdrawn semaglutide

What happens when patients stop semaglutide after run-in.

STEP 5 · 2022 · 104 wks

STEP 5 — Long-term semaglutide treatment

Two-year semaglutide treatment.

STEP-HFpEF · 2023 · 52 wks

STEP-HFpEF — Semaglutide in heart failure with preserved EF

Semaglutide in adults with obesity-related HFpEF.

SELECT · 2023 · 208 wks

SELECT — Semaglutide and cardiovascular outcomes

Cardiovascular outcomes in non-diabetic adults with established CVD.

SURMOUNT-1 · 2022 · 72 wks

SURMOUNT-1 — Tirzepatide for weight management

Pivotal trial of tirzepatide for chronic weight management without diabetes.

SURMOUNT-2 · 2023 · 72 wks

SURMOUNT-2 — Tirzepatide in T2D

Tirzepatide in adults with overweight/obesity AND T2D.

SURMOUNT-3 · 2023 · 72 wks

SURMOUNT-3 — Tirzepatide after intensive lifestyle intervention

Tirzepatide initiated after lifestyle intervention.

SURMOUNT-OSA · 2024 · 52 wks

SURMOUNT-OSA — Tirzepatide for sleep apnea

Tirzepatide in adults with obesity and moderate-severe OSA.

FLOW · 2024 · 156 wks

FLOW — Semaglutide kidney outcomes in T2D

Semaglutide and progression of kidney disease in T2D.

Get matched

Want a real recommendation?

Five minutes. Free. No pressure.

Start my consultation