STEP 1 · 2021

STEP 1 — Semaglutide for weight management

Pivotal trial of semaglutide 2.4 mg weekly for chronic weight management in adults without diabetes.

Headline finding

14.9% body-weight reduction at 68 weeks vs 2.4% placebo.

Population
1,961 adults, BMI ≥30 or ≥27 with comorbidity
Duration
68 weeks
Citation
Wilding JPH et al., NEJM 2021

Summary is editorial; consult the original publication for the full methodology and statistical detail.

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