STEP 4 · 2021

STEP 4 — Effect of continued vs withdrawn semaglutide

What happens when patients stop semaglutide after run-in.

Headline finding

Continuing produced an additional 7.9% weight reduction; switching to placebo led to weight regain.

Population
803 adults completing 20-week run-in
Duration
68 weeks
Citation
Rubino D et al., JAMA 2021

Summary is editorial; consult the original publication for the full methodology and statistical detail.

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